Risks and benefits of aromatase inhibitors in postmenopausal breast cancer

So if you’ve got Arimidex in your possession, you’re not going to come under the same scrutiny as if you were carrying steroids. Arimidex isn’t a banned substance by WADA or other organizations as it hasn’t been recognized as having any performance-enhancing benefits. Other uncommon possible side effects of Arimidex include fatigue, headache, nausea, and hot flashes. Still, once again, these are almost always only seen in women who use Arimidex for long periods. While a reduction in HDL is almost always reversible after stopping steroids, following a diet low in saturated fat and higher in cholesterol-friendly foods like those rich in omega-3 fatty acids is still critical. Cardio work is also advised so you can keep cholesterol levels as optimal as possible during this time.

Aromatase (CYP19A) Activity Assay Kit (Fluorometric)

• But if they become more severe or don’t go away, talk with your doctor or pharmacist.
• Anastrozole is the most commonly used aromatase inhibitor and is FDA approved for the treatment of breast cancer in women.
• Although the changes of pregnancy are low in post-menopausal women, you should call your doctor right away if you become pregnant while on exemestane, as it may harm the fetus.
• Arimidex is sometimes taken to lower estrogen levels that are high due to anabolic steroid use.
• AROMASIN 25MG TABLET is not recommended for use among pregnant and breastfeeding women.
• A number of studies showed that estrogen decreases Ang II-induced aldosterone secretion 100.

Further research found that Vitamin D (also known as calcitriol) doesn’t just block both the production and the uptake of aromatase. It also enhances anti-estrogenic compounds like anastrozole, exemestane, and letrozole. Your endocrine system (the organs and processes that govern hormones including testosterone and estrogen) works in a narrow balance.

3.2. Meta-analyses showing non-significant increase of CVD with AIs

In breast cancer increased aromatase activity elevates estrogen levels promoting cancer cell growth. Anti-aromatase drugs like aromatase inhibitors target this enzyme to lower estrogen production. Additionally defects in aromatase activity can lead to disorders like aromatase deficiency resulting in an imbalance in sex hormone levels. Understanding its function aids in the development of therapies targeting proteins like the estrogen receptor which interacts with products of aromatase activity.

Additionally, these medications can increase testosterone production, as a small but groundbreaking study discovered as early as 2004. This approach to treating low testosterone is known as testosterone restoration, as opposed to testosterone replacement. One of the primary functions of Arimidrol is to control estrogen levels in the body, which is essential in achieving muscle growth.

This will include primarily SERMs for PCT, while there are other AIs you can choose for on-cycle use, and it’s worth comparing these to Arimidex. Since we will rarely want to use Arimidex as part of PCT, your use of it will typically stop at the end M-JECT 100 mg Muscule Pharm of your steroid cycle. If you run Arimidex during PCT, a standard cycle length still applies for 4-6 weeks.

Before you start taking Arimidex, talk with your doctor about any other medical conditions you have and other medications you take. In some cases, Arimidex may not be the best treatment option for you. Below are some medications and medical conditions that you should discuss with your doctor before starting Arimidex. Serious side effects from Arimidex can occur, but they aren’t common. If you have serious side effects from Arimidex, call your doctor right away. But if you think you’re having a medical emergency, you should call 911 or your local emergency number.

However, the drug may be prescribed off-label for this use according to guidelines from the American Society of Clinical Oncology. A large clinical trial studied Aromasin as adjuvant therapy for breast cancer. Aromasin can lower the amount of estrogen your body makes by 85% to 95%. This is why Aromasin is FDA-approved only for women who are postmenopausal (have gone through menopause) and have ovaries that aren’t as active. After you’ve gone through menopause (stopped having your period), your ovaries produce much less estrogen.

Many phytoestrogens or polyphenolic compounds were discovered at about the same time as steroid hormones. For example, resveratrol, a polyphenolic stilbene, was first isolated by Takaoka in the 1940s 36. Later Nonomura isolated resveratrol from Japanese knotweed (Pediomelum cuspidatum) in 1963 37 with subsequent studies demonstrating that resveratrol was found in red grapes (wine) in 1992 by Siemann and Creasy 38. Later, Bertelli et al., in 1995, reported that resveratrol had some cardioprotective effects 39.